INFN Roma Tre Section is currently developing a new generation of gamma camera for Nuclear Medicine application. A continuous research on new scintillation crystals, photodetectors and electronic readout is needed to allow a better spatial resolution, energy resolution and overall efficiency. Our group, with the help of other national and international research groups, like Policlinico Umberto I and Johns Hopkins Medical School, develop prototypes of application specific compact gamma camera, from the choose of crystal and photodetector to the develop of the electronic readout, mechanical frame and control software.